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Sermorelin

Growth Hormone SecretagogueResearch Use Only

Also known as: GRF 1-29, GHRH 1-29, Sermorelin acetate

One of the oldest GH-releasing peptides, formerly a prescription drug; a gentle way to nudge natural GH at night.

Dosing quick reference

research reference
Starting dose
200 mcg once daily (bedtime)
Frequency
Once daily (bedtime)
Typical range
200–500 mcg per day
Cycle
3–6 months
Titration (step-up)
Increase ~100 mcg every 1–2 weeks: 200 → 300 → 400 → 500 mcg
Half-life
~10–20 minutes (very short-acting)
Route
Subcutaneous (research)
Common use
Studied as a GHRH analog for stimulating natural growth-hormone release in research
Common vial sizes
5 mg · 10 mg
Storage
Lyophilized powder stored refrigerated or frozen away from light; reconstituted solution refrigerated (2–8 °C) and used within a few weeks
Stacking notes
Commonly paired with a GHRP such as GHRP-2 or Ipamorelin in research protocols

Reported side effects

Injection-site reactionFlushing reported anecdotallyTransient headache reported anecdotally
Regulatory note: Previously an approved diagnostic agent in some jurisdictions; current research-market products are sold for research purposes only
Calculate a dose →Sermorelin on The Peptide Guide →Deeper research reference: literature dose ranges, storage and handling, and where to source in Canada.

Dose figures are ranges commonly referenced in research literature, not recommendations or medical advice. Research-only labeling does not establish that a substance is safe, approved or appropriate for personal use. Consult a qualified healthcare professional about health decisions.